Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma

We have shown that the proteasome inhibitor bortezomib (formerly known as PS-341) triggers significant antitumor activity in multiple myeloma (MM) in both preclinical models and patients with relapsed refractory disease. Recent studies have shown that unfolded and misfolded ubiquitinated proteins ar...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Hideshima, Teru, Bradner, James E., Wong, Jason, Chauhan, Dharminder, Richardson, Paul, Schreiber, Stuart L., Anderson, Kenneth C.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2005
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1150844/
https://ncbi.nlm.nih.gov/pubmed/15937109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503221102
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki