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Loss of G–A base pairs is insufficient for achieving a large opening of U4 snRNA K-turn motif

Upon binding to the 15.5K protein, two tandem-sheared G–A base pairs are formed in the internal loop of the kink-turn motif of U4 snRNA (Kt-U4). We have reported that the folding of Kt-U4 is assisted by protein binding. Unstable interactions that contribute to a large opening of the free RNA (‘k–e m...

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Autors principals: Cojocaru, Vlad, Klement, Reinhard, Jovin, Thomas M.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1150281/
https://ncbi.nlm.nih.gov/pubmed/15956103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki664
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