Two Overlapping Subdominant Epitopes Identified by DNA Immunization Induce Protective CD8(+) T-Cell Populations with Differing Cytolytic Activities

Subdominant CD8(+) T-cell responses contribute to control of several viral infections and to vaccine-induced immunity. Here, using the lymphocytic choriomeningitis virus model, we demonstrate that subdominant epitopes can be more reliably identified by DNA immunization than by other methods, permitt...

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Dettagli Bibliografici

Pubblicato in:	J Virol
Autori principali:	Rodriguez, Fernando, Slifka, Mark K., Harkins, Stephanie, Whitton, J. Lindsay
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Pathogenesis and Immunity
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114975/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11462012/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.16.7399-7409.2001
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