Two Overlapping Subdominant Epitopes Identified by DNA Immunization Induce Protective CD8(+) T-Cell Populations with Differing Cytolytic Activities

Subdominant CD8(+) T-cell responses contribute to control of several viral infections and to vaccine-induced immunity. Here, using the lymphocytic choriomeningitis virus model, we demonstrate that subdominant epitopes can be more reliably identified by DNA immunization than by other methods, permitt...

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Bibliographic Details
Main Authors: Rodriguez, Fernando, Slifka, Mark K., Harkins, Stephanie, Whitton, J. Lindsay
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC114975/
https://ncbi.nlm.nih.gov/pubmed/11462012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.16.7399-7409.2001
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