Efficient Transmission of Two Different Sheep Scrapie Isolates in Transgenic Mice Expressing the Ovine PrP Gene

We produced transgenic mice expressing the sheep prion protein to obtain a sensitive model for sheep spongiform encephalopathies (scrapie). The complete open reading frame, with alanine, arginine, and glutamine at susceptibility codons 136, 154, and 171, respectively, was inserted downstream from th...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Crozet, Carole, Flamant, Frederic, Bencsik, Anna, Aubert, Denise, Samarut, Jacques, Baron, Thierry
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2001
Gaiak:
Pathogenesis and Immunity
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC114937/
https://ncbi.nlm.nih.gov/pubmed/11333913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.11.5328-5334.2001
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