Efficient Transmission of Two Different Sheep Scrapie Isolates in Transgenic Mice Expressing the Ovine PrP Gene

We produced transgenic mice expressing the sheep prion protein to obtain a sensitive model for sheep spongiform encephalopathies (scrapie). The complete open reading frame, with alanine, arginine, and glutamine at susceptibility codons 136, 154, and 171, respectively, was inserted downstream from th...

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Pubblicato in:	J Virol
Autori principali:	Crozet, Carole, Flamant, Frederic, Bencsik, Anna, Aubert, Denise, Samarut, Jacques, Baron, Thierry
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Pathogenesis and Immunity
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114937/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11333913/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.11.5328-5334.2001
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