Efficient Transmission of Two Different Sheep Scrapie Isolates in Transgenic Mice Expressing the Ovine PrP Gene

We produced transgenic mice expressing the sheep prion protein to obtain a sensitive model for sheep spongiform encephalopathies (scrapie). The complete open reading frame, with alanine, arginine, and glutamine at susceptibility codons 136, 154, and 171, respectively, was inserted downstream from th...

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Detaylı Bibliyografya
Asıl Yazarlar: Crozet, Carole, Flamant, Frederic, Bencsik, Anna, Aubert, Denise, Samarut, Jacques, Baron, Thierry
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2001
Konular:
Pathogenesis and Immunity
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC114937/
https://ncbi.nlm.nih.gov/pubmed/11333913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.11.5328-5334.2001
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