Polyomavirus Small t Antigen Prevents Retinoic Acid-Induced Retinoblastoma Protein Hypophosphorylation and Redirects Retinoic Acid-Induced G(0) Arrest and Differentiation to Apoptosis

Polyomavirus small t antigen (ST) impedes late features of retinoic acid (RA)-induced HL-60 myeloid differentiation as well as growth arrest, causing apoptosis instead. HL-60 cells were stably transfected with ST. ST slowed the cell cycle, retarding G(2)/M in particular. Treated with RA, the ST tran...

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Autori principali: Yen, Andrew, Placanica, Lisa, Bloom, Stephen, Varvayanis, Susi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
Soggetti:
Virus-Cell Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC114935/
https://ncbi.nlm.nih.gov/pubmed/11333911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.11.5302-5314.2001
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