A Herpes Simplex Virus Type 1 γ34.5 Second-Site Suppressor Mutant That Exhibits Enhanced Growth in Cultured Glioblastoma Cells Is Severely Attenuated in Animals

We describe here the neurovirulence properties of a herpes simplex virus type 1 γ34.5 second-site suppressor mutant. γ34.5 mutants are nonneurovirulent in animals and fail to grow in a variety of cultured cells due to a block at the level of protein synthesis. Extragenic suppressors with restored ca...

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Autori principali: Mohr, Ian, Sternberg, David, Ward, Stephen, Leib, David, Mulvey, Matthew, Gluzman, Yakov
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC114924/
https://ncbi.nlm.nih.gov/pubmed/11333900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.11.5189-5196.2001
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