Murine Coronavirus Spike Protein Determines the Ability of the Virus To Replicate in the Liver and Cause Hepatitis

Recombinant mouse hepatitis viruses (MHV) differing only in the spike gene, containing A59, MHV-4, and MHV-2 spike genes in the background of the A59 genome, were compared for their ability to replicate in the liver and induce hepatitis in weanling C57BL/6 mice infected with 500 PFU of each virus by...

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Detalhes bibliográficos
Main Authors: Navas, Sonia, Seo, Su-Hun, Chua, Ming Ming, Sarma, Jayasri Das, Lavi, Ehud, Hingley, Susan T., Weiss, Susan R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114828/
https://ncbi.nlm.nih.gov/pubmed/11160748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.5.2452-2457.2001
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