Partial Restoration of Replication of Simian Immunodeficiency Virus by Point Mutations in either the Dimerization Initiation Site (DIS) or Gag Region after Deletion Mutagenesis within the DIS

We used the simian immunodeficiency virus (SIV) molecular clone SIVmac239 to generate a deletion construct, termed SD2, in which we eliminated 22 nucleotides at positions +398 to +418 within the putative dimerization initiation site (DIS) stem. This SD2 deletion severely impaired viral replication,...

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Bibliografiske detaljer
Main Authors: Guan, Yongjun, Diallo, Karidia, Detorio, Mervi, Whitney, James B., Liang, Chen, Wainberg, Mark A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC114782/
https://ncbi.nlm.nih.gov/pubmed/11689677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.23.11920-11923.2001
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