Reducing the Native Tropism of Adenovirus Vectors Requires Removal of both CAR and Integrin Interactions

The development of tissue-selective virus-based vectors requires a better understanding of the role of receptors in gene transfer in vivo, both to rid the vectors of their native tropism and to introduce new specificity. CAR and αv integrins have been identified as the primary cell surface component...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Einfeld, David A., Schroeder, Rosanna, Roelvink, Peter W., Lizonova, Alena, King, C. Richter, Kovesdi, Imre, Wickham, Thomas J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2001
Ämnen:
Gene Therapy
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC114713/
https://ncbi.nlm.nih.gov/pubmed/11689608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.23.11284-11291.2001
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk