Reducing the Native Tropism of Adenovirus Vectors Requires Removal of both CAR and Integrin Interactions

The development of tissue-selective virus-based vectors requires a better understanding of the role of receptors in gene transfer in vivo, both to rid the vectors of their native tropism and to introduce new specificity. CAR and αv integrins have been identified as the primary cell surface component...

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Detalles Bibliográficos
Main Authors: Einfeld, David A., Schroeder, Rosanna, Roelvink, Peter W., Lizonova, Alena, King, C. Richter, Kovesdi, Imre, Wickham, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2001
Assuntos:
Gene Therapy
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC114713/
https://ncbi.nlm.nih.gov/pubmed/11689608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.23.11284-11291.2001
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