Reducing the Native Tropism of Adenovirus Vectors Requires Removal of both CAR and Integrin Interactions

The development of tissue-selective virus-based vectors requires a better understanding of the role of receptors in gene transfer in vivo, both to rid the vectors of their native tropism and to introduce new specificity. CAR and αv integrins have been identified as the primary cell surface component...

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Main Authors: Einfeld, David A., Schroeder, Rosanna, Roelvink, Peter W., Lizonova, Alena, King, C. Richter, Kovesdi, Imre, Wickham, Thomas J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology (ASM) 2001
Ábhair:
Gene Therapy
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC114713/
https://ncbi.nlm.nih.gov/pubmed/11689608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.23.11284-11291.2001
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