PE2 Cleavage Mutants of Sindbis Virus: Correlation between Viral Infectivity and pH-Dependent Membrane Fusion Activation of the Spike Heterodimer

The spike glycoprotein E2 of Sindbis virus (SIN) is synthesized in the infected cell as a PE2 precursor protein, which matures through cleavage by a cellular furin-like protease. Previous work has shown that SIN mutants impaired in PE2 cleavage are noninfectious on BHK-21 cells, the block in infecti...

Celý popis

Podrobná bibliografie

Vydáno v:	J Virol
Hlavní autoři:	Smit, Jolanda M., Klimstra, William B., Ryman, Kate D., Bittman, Robert, Johnston, Robert E., Wilschut, Jan
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2001
Témata:	Virus-Cell Interactions
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114699/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11602759/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.22.11196-11204.2001
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!