PE2 Cleavage Mutants of Sindbis Virus: Correlation between Viral Infectivity and pH-Dependent Membrane Fusion Activation of the Spike Heterodimer

The spike glycoprotein E2 of Sindbis virus (SIN) is synthesized in the infected cell as a PE2 precursor protein, which matures through cleavage by a cellular furin-like protease. Previous work has shown that SIN mutants impaired in PE2 cleavage are noninfectious on BHK-21 cells, the block in infecti...

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הוצא לאור ב:	J Virol
Principais autores:	Smit, Jolanda M., Klimstra, William B., Ryman, Kate D., Bittman, Robert, Johnston, Robert E., Wilschut, Jan
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	American Society for Microbiology (ASM) 2001
נושאים:	Virus-Cell Interactions
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114699/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11602759/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.22.11196-11204.2001
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