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mRNA Decay during Herpesvirus Infections: Interaction between a Putative Viral Nuclease and a Cellular Translation Factor

During lytic infections, the virion host shutoff (Vhs) protein (UL41) of herpes simplex virus destabilizes both host and viral mRNAs. By accelerating mRNA decay, it helps determine the levels and kinetics of viral and cellular gene expression. In vivo, Vhs shows a strong preference for mRNAs, as opp...

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Bibliografiske detaljer
Main Authors: Feng, Pinghui, Everly, David N., Read, G. Sullivan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC114601/
https://ncbi.nlm.nih.gov/pubmed/11581395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.21.10272-10280.2001
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