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Small Interfering RNAs That Deplete the Cellular Translation Factor eIF4H Impede mRNA Degradation by the Virion Host Shutoff Protein of Herpes Simplex Virus

The herpes simplex virus (HSV) virion host shutoff (Vhs) protein is an endoribonuclease that accelerates decay of many host and viral mRNAs. Purified Vhs does not distinguish mRNAs from nonmessenger RNAs and cuts target RNAs at many sites, yet within infected cells it is targeted to mRNAs and cleave...

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Autors principals: Sarma, Nandini, Agarwal, Deepali, Shiflett, Lora A., Read, G. Sullivan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447072/
https://ncbi.nlm.nih.gov/pubmed/18448541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00137-08
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