Systematic Identification of Antiprion Drugs by High-Throughput Screening Based on Scanning for Intensely Fluorescent Targets

Conformational changes and aggregation of specific proteins are hallmarks of a number of diseases, like Alzheimer's disease, Parkinson's disease, and prion diseases. In the case of prion diseases, the prion protein (PrP), a neuronal glycoprotein, undergoes a conformational change from the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Bertsch, Uwe, Winklhofer, Konstanze F., Hirschberger, Thomas, Bieschke, Jan, Weber, Petra, Hartl, F. Ulrich, Tavan, Paul, Tatzelt, Jörg, Kretzschmar, Hans A., Giese, Armin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1143673/
https://ncbi.nlm.nih.gov/pubmed/15919931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.12.7785-7791.2005
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