Intestinal Dysplasia Induced by Simian Virus 40 T Antigen Is Independent of p53

Transgenic mice expressing simian virus 40 large T antigen in enterocytes develop intestinal hyperplasia that progresses to dysplasia with age. Hyperplasia is dependent on T antigen binding to the retinoblastoma (pRb) family of tumor suppressor proteins. Mice expressing a truncated T antigen that in...

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Bibliographic Details
Main Authors: Markovics, Jennifer A., Carroll, Patrick A., Robles, M. Teresa Sáenz, Pope, Hannah, Coopersmith, Craig M., Pipas, James M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Transformation and Oncogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1143657/
https://ncbi.nlm.nih.gov/pubmed/15919904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.12.7492-7502.2005
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