Simian virus 40 T antigen can regulate p53-mediated transcription independent of binding p53.

A simian virus 40 (SV40) T-antigen mutant containing only the N-terminal 136 amino acids, able to bind to Rb and p300 but not p53, partially inhibited p53-mediated transcription without affecting the ability of p53 to bind DNA. These results suggest that SV40 T antigen can regulate p53-mediated tran...

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Bibliographic Details
Main Authors: Rushton, J J, Jiang, D, Srinivasan, A, Pipas, J M, Robbins, P D
Format: Artigo
Language:Inglês
Published: 1997
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC191805/
https://ncbi.nlm.nih.gov/pubmed/9188637
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