p21cip1 Degradation in Differentiated Keratinocytes Is Abrogated by Costabilization with Cyclin E Induced by Human Papillomavirus E7

The human papillomavirus (HPV) E7 protein promotes S-phase reentry in a fraction of postmitotic, differentiated keratinocytes. Here we report that these cells contain an inherent mechanism that opposes E7-induced DNA replication. In organotypic raft cultures of primary human keratinocytes, neither c...

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Autori principali: Noya, Francisco, Chien, Wei-Ming, Broker, Thomas R., Chow, Louise T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
Soggetti:
Virus-Cell Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC114328/
https://ncbi.nlm.nih.gov/pubmed/11390614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.13.6121-6134.2001
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