Generation of a Highly Pathogenic Avian Influenza A Virus from an Avirulent Field Isolate by Passaging in Chickens

Highly virulent avian influenza viruses can arise from avirulent strains maintained in poultry, but evidence to support their generation from viruses in wild birds is lacking. The most likely mechanism for the acquisition of virulence by benign avian viruses is the introduction of mutations by error...

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Hlavní autoři: Ito, Toshihiro, Goto, Hideo, Yamamoto, Eiji, Tanaka, Hiroko, Takeuchi, Mutsuko, Kuwayama, Masaru, Kawaoka, Yoshihiro, Otsuki, Koichi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2001
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC114193/
https://ncbi.nlm.nih.gov/pubmed/11287597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.9.4439-4443.2001
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