Vaccinia Virus Blocks Gamma Interferon Signal Transduction: Viral VH1 Phosphatase Reverses Stat1 Activation

We have analyzed the effects of vaccinia virus (VV) on gamma interferon (IFN-γ) signal transduction. Infection of cells with VV 1 to 2 h prior to treatment with IFN-γ inhibits phosphorylation and nuclear translocation of Stat1 and consequently blocks accumulation of mRNAs normally induced by IFN-γ....

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Pubblicato in:	J Virol
Autori principali:	Najarro, Pilar, Traktman, Paula, Lewis, John A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Virus-Cell Interactions
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114112/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11238845/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.7.3185-3196.2001
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