Vaccinia Virus Blocks Gamma Interferon Signal Transduction: Viral VH1 Phosphatase Reverses Stat1 Activation

We have analyzed the effects of vaccinia virus (VV) on gamma interferon (IFN-γ) signal transduction. Infection of cells with VV 1 to 2 h prior to treatment with IFN-γ inhibits phosphorylation and nuclear translocation of Stat1 and consequently blocks accumulation of mRNAs normally induced by IFN-γ....

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Hlavní autoři: Najarro, Pilar, Traktman, Paula, Lewis, John A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2001
Témata:
Virus-Cell Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC114112/
https://ncbi.nlm.nih.gov/pubmed/11238845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.7.3185-3196.2001
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