Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir

Penciclovir (PCV), an antiherpesvirus agent in the same class as acyclovir (ACV), is phosphorylated in herpes simplex virus (HSV)-infected cells by the viral thymidine kinase (TK). Resistance to ACV has been mapped to mutations within either the TK or the DNA polymerase gene. An identical activation...

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Vydáno v:	J Virol
Hlavní autoři:	Sarisky, Robert T., Quail, Matthew R., Clark, Philip E., Nguyen, Tammy T., Halsey, Wendy S., Wittrock, Robert J., Bartus, Joan O'Leary, Van Horn, Marion M., Sathe, Ganesh M., Van Horn, Stephanie, Kelly, Michael D., Bacon, Teresa H., Leary, Jeffry J.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2001
Témata:	Vaccines and Antiviral Agents
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114085/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11160674/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.4.1761-1769.2001
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