Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir

Penciclovir (PCV), an antiherpesvirus agent in the same class as acyclovir (ACV), is phosphorylated in herpes simplex virus (HSV)-infected cells by the viral thymidine kinase (TK). Resistance to ACV has been mapped to mutations within either the TK or the DNA polymerase gene. An identical activation...

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Bibliografiske detaljer

Udgivet i:	J Virol
Principais autores:	Sarisky, Robert T., Quail, Matthew R., Clark, Philip E., Nguyen, Tammy T., Halsey, Wendy S., Wittrock, Robert J., Bartus, Joan O'Leary, Van Horn, Marion M., Sathe, Ganesh M., Van Horn, Stephanie, Kelly, Michael D., Bacon, Teresa H., Leary, Jeffry J.
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 2001
Fag:	Vaccines and Antiviral Agents
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114085/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11160674/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.4.1761-1769.2001
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