Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir

Penciclovir (PCV), an antiherpesvirus agent in the same class as acyclovir (ACV), is phosphorylated in herpes simplex virus (HSV)-infected cells by the viral thymidine kinase (TK). Resistance to ACV has been mapped to mutations within either the TK or the DNA polymerase gene. An identical activation...

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Detalles Bibliográficos
Main Authors: Sarisky, Robert T., Quail, Matthew R., Clark, Philip E., Nguyen, Tammy T., Halsey, Wendy S., Wittrock, Robert J., Bartus, Joan O'Leary, Van Horn, Marion M., Sathe, Ganesh M., Van Horn, Stephanie, Kelly, Michael D., Bacon, Teresa H., Leary, Jeffry J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC114085/
https://ncbi.nlm.nih.gov/pubmed/11160674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.4.1761-1769.2001
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