Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir

Penciclovir (PCV), an antiherpesvirus agent in the same class as acyclovir (ACV), is phosphorylated in herpes simplex virus (HSV)-infected cells by the viral thymidine kinase (TK). Resistance to ACV has been mapped to mutations within either the TK or the DNA polymerase gene. An identical activation...

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Detalhes bibliográficos
Main Authors: Sarisky, Robert T., Quail, Matthew R., Clark, Philip E., Nguyen, Tammy T., Halsey, Wendy S., Wittrock, Robert J., Bartus, Joan O'Leary, Van Horn, Marion M., Sathe, Ganesh M., Van Horn, Stephanie, Kelly, Michael D., Bacon, Teresa H., Leary, Jeffry J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114085/
https://ncbi.nlm.nih.gov/pubmed/11160674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.4.1761-1769.2001
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