Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir

Penciclovir (PCV), an antiherpesvirus agent in the same class as acyclovir (ACV), is phosphorylated in herpes simplex virus (HSV)-infected cells by the viral thymidine kinase (TK). Resistance to ACV has been mapped to mutations within either the TK or the DNA polymerase gene. An identical activation...

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में प्रकाशित:	J Virol
मुख्य लेखकों:	Sarisky, Robert T., Quail, Matthew R., Clark, Philip E., Nguyen, Tammy T., Halsey, Wendy S., Wittrock, Robert J., Bartus, Joan O'Leary, Van Horn, Marion M., Sathe, Ganesh M., Van Horn, Stephanie, Kelly, Michael D., Bacon, Teresa H., Leary, Jeffry J.
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	American Society for Microbiology (ASM) 2001
विषय:	Vaccines and Antiviral Agents
ऑनलाइन पहुंच:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114085/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11160674/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.4.1761-1769.2001
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