In Vivo HP1 Targeting Causes Large-Scale Chromatin Condensation and Enhanced Histone Lysine Methylation

Changes in chromatin structure are a key aspect in the epigenetic regulation of gene expression. We have used a lac operator array system to visualize by light microscopy the effect of heterochromatin protein 1 (HP1) α (HP1α) and HP1β on large-scale chromatin structure in living mammalian cells. The...

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Detalhes bibliográficos
Main Authors: Verschure, Pernette J., van der Kraan, Ineke, de Leeuw, Wim, van der Vlag, Johan, Carpenter, Anne E., Belmont, Andrew S., van Driel, Roel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Chromosome Structure and Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140641/
https://ncbi.nlm.nih.gov/pubmed/15899859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.11.4552-4564.2005
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