A Role for MeCP2 in Switching Gene Activity via Chromatin Unfolding and HP1γ Displacement

Methyl-CpG-binding protein 2 (MeCP2) is generally considered to act as a transcriptional repressor, whereas recent studies suggest that MeCP2 is also involved in transcription activation. To gain insight into this dual function of MeCP2, we assessed the impact of MeCP2 on higher-order chromatin stru...

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Main Authors: Brink, Maartje C., Piebes, Diewertje G. E., de Groote, Marloes L., Luijsterburg, Martijn S., Casas-Delucchi, Corella S., van Driel, Roel, Rots, Marianne G., Cardoso, M. Cristina, Verschure, Pernette J.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3720725/
https://ncbi.nlm.nih.gov/pubmed/23935992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069347
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