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Detection by Denaturing Gradient Gel Electrophoresis of pncA Mutations Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis Isolates from the United States-Mexico Border Region

Denaturing gradient gel electrophoresis (DGGE) was used to probe for mutations associated with pyrazinamide (PZA) resistance in the pncA gene of Mycobacterium tuberculosis. DGGE scans for mutations across large regions of DNA and rivals sequencing in its ability to detect DNA alterations. Specific m...

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Detalhes bibliográficos
Main Authors: McCammon, Mark T., Gillette, John S., Thomas, Derek P., Ramaswamy, Srinivas V., Rosas, Ishmael I., Graviss, Edward A., Vijg, Jan, Quitugua, Teresa N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140546/
https://ncbi.nlm.nih.gov/pubmed/15917514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.6.2210-2217.2005
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