Detection by Denaturing Gradient Gel Electrophoresis of pncA Mutations Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis Isolates from the United States-Mexico Border Region

Denaturing gradient gel electrophoresis (DGGE) was used to probe for mutations associated with pyrazinamide (PZA) resistance in the pncA gene of Mycobacterium tuberculosis. DGGE scans for mutations across large regions of DNA and rivals sequencing in its ability to detect DNA alterations. Specific m...

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Hauptverfasser: McCammon, Mark T., Gillette, John S., Thomas, Derek P., Ramaswamy, Srinivas V., Rosas, Ishmael I., Graviss, Edward A., Vijg, Jan, Quitugua, Teresa N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140546/
https://ncbi.nlm.nih.gov/pubmed/15917514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.6.2210-2217.2005
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