Detection of rpoB Mutations Associated with Rifampin Resistance in Mycobacterium tuberculosis Using Denaturing Gradient Gel Electrophoresis

Denaturing gradient gel electrophoresis (DGGE) was used to probe for mutations associated with rifampin (RIF) resistance in the rpoB gene of Mycobacterium tuberculosis. DGGE scans for mutations across large regions of DNA and is comparable to DNA sequencing in detecting DNA alterations. Specific mut...

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Hauptverfasser: McCammon, Mark T., Gillette, John S., Thomas, Derek P., Ramaswamy, Srinivas V., Graviss, Edward A., Kreiswirth, Barry N., Vijg, Jan, Quitugua, Teresa N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140537/
https://ncbi.nlm.nih.gov/pubmed/15917513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.6.2200-2209.2005
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