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Structure guided prediction of Pyrazinamide resistance mutations in pncA
Pyrazinamide plays an important role in tuberculosis treatment; however, its use is complicated by side-effects and challenges with reliable drug susceptibility testing. Resistance to pyrazinamide is largely driven by mutations in pyrazinamidase (pncA), responsible for drug activation, but genetic h...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7002382/ https://ncbi.nlm.nih.gov/pubmed/32024884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58635-x |
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