Characterization of pncA Mutations in Pyrazinamide-Resistant Mycobacterium tuberculosis in Brazil

In this study the nucleotide sequence of the pncA gene from 59 Mycobacterium tuberculosis clinical isolates was analyzed. Mutations in the pncA gene were identified in 29 of 40 pyrazinamide-resistant isolates, and no pyrazinamidase activity was detected in 39 of them. Twelve mutations found in this...

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Bibliographische Detailangaben
Hauptverfasser: Rodrigues, Vívian de F. Sumnienski, Telles, Maria Alice, Ribeiro, Marta Osório, Cafrune, Patrícia Izquierdo, Rossetti, Maria Lucia Rosa, Zaha, Arnaldo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC538919/
https://ncbi.nlm.nih.gov/pubmed/15616332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.1.444-446.2005
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