Characterization of pncA Mutations in Pyrazinamide-Resistant Mycobacterium tuberculosis in Brazil

In this study the nucleotide sequence of the pncA gene from 59 Mycobacterium tuberculosis clinical isolates was analyzed. Mutations in the pncA gene were identified in 29 of 40 pyrazinamide-resistant isolates, and no pyrazinamidase activity was detected in 39 of them. Twelve mutations found in this...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Rodrigues, Vívian de F. Sumnienski, Telles, Maria Alice, Ribeiro, Marta Osório, Cafrune, Patrícia Izquierdo, Rossetti, Maria Lucia Rosa, Zaha, Arnaldo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2005
Assuntos:	Mechanisms of Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC538919/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15616332/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.49.1.444-446.2005
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