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Use of Intron-Disrupted Polyadenylation Sites To Enhance Expression and Safety of Retroviral Vectors
Normal mRNA polyadenylation signals are composed of an AAUAAA motif and G/U box spaced 20 to 30 bp apart. If this spacing is increased further, then polyadenylation is disrupted. Previously it has been demonstrated that insertion of an intron will similarly disrupt this signal even though such intro...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology
2001
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC113913/ https://ncbi.nlm.nih.gov/pubmed/11119589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.1.199-204.2001 |
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