Identification of three critical acidic residues of poly(ADP-ribose) glycohydrolase involved in catalysis: determining the PARG catalytic domain

PARG [poly(ADP-ribose) glycohydrolase] catalyses the hydrolysis of α(1″→2′) or α(1‴→2″) O-glycosidic linkages of ADP-ribose polymers to produce free ADP-ribose. We investigated possible mechanistic similarities between PARG and glycosidases, which also cleave O-glycosidic linkages. Glycosidases typi...

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Bibliografske podrobnosti
Main Authors: Patel, Chandra N., Koh, David W., Jacobson, Myron K., Oliveira, Marcos A.
Format: Artigo
Jezik:Inglês
Izdano: Portland Press Ltd. 2005
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1138956/
https://ncbi.nlm.nih.gov/pubmed/15658938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040942
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