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Heme-regulated eIF2α kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and β-thalassemia

Heme-regulated eIF2α kinase (HRI) controls protein synthesis by phosphorylating the α-subunit of eukaryotic translational initiation factor 2 (eIF2α). In heme deficiency, HRI is essential for translational regulation of α- and β-globins and for the survival of erythroid progenitors. HRI is also acti...

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Bibliografski detalji
Glavni autori: Han, An-Ping, Fleming, Mark D., Chen, Jane-Jane
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2005
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1136998/
https://ncbi.nlm.nih.gov/pubmed/15931390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24141
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