Heme-regulated eIF2α kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and β-thalassemia

Heme-regulated eIF2α kinase (HRI) controls protein synthesis by phosphorylating the α-subunit of eukaryotic translational initiation factor 2 (eIF2α). In heme deficiency, HRI is essential for translational regulation of α- and β-globins and for the survival of erythroid progenitors. HRI is also acti...

Full description

Saved in:
Bibliographic Details
Main Authors: Han, An-Ping, Fleming, Mark D., Chen, Jane-Jane
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2005
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1136998/
https://ncbi.nlm.nih.gov/pubmed/15931390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24141
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items