Dissociation and unfolding of the pyruvate dehydrogenase complex by guanidinium chloride.

The effect of guanidinium chloride (GdnHCl) on the pyruvate dehydrogenase complex (PDC) from bovine heart and its constituent enzymes has been studied. The overall activity of the complex is lost reversibly at low levels of GdnHCl (0.2 M) which cause 40-50% inactivation but no loss of overall second...

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Bibliografiske detaljer
Main Authors: West, S M, Rice, J E, Beaumont, E S, Kelly, S M, Price, N C, Lindsay, J G
Format: Artigo
Sprog:Inglês
Udgivet: 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1136825/
https://ncbi.nlm.nih.gov/pubmed/8948465
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