Dissociation and unfolding of the pyruvate dehydrogenase complex by guanidinium chloride.

The effect of guanidinium chloride (GdnHCl) on the pyruvate dehydrogenase complex (PDC) from bovine heart and its constituent enzymes has been studied. The overall activity of the complex is lost reversibly at low levels of GdnHCl (0.2 M) which cause 40-50% inactivation but no loss of overall second...

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Bibliografische gegevens
Hoofdauteurs: West, S M, Rice, J E, Beaumont, E S, Kelly, S M, Price, N C, Lindsay, J G
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1995
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1136825/
https://ncbi.nlm.nih.gov/pubmed/8948465
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