Inactivation during denaturation of ribonuclease A by guanidinium chloride is accompanied by unfolding at the active site.

Inactivation of pancreatic RNAase A occurs in guanidinium chloride (GdmCl) at low concentrations before the unfolding of the molecule as a whole can be detected [Liu and Tsou (1987) Biochim. Biophys. Acta 916, 455-464]. We have now shown that the rate of digestion of the RNAase molecule by either tr...

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Bibliographic Details
Main Authors: Yang, H J, Tsou, C L
Format: Artigo
Language:Inglês
Published: 1995
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1136372/
https://ncbi.nlm.nih.gov/pubmed/7832749
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