The homeodomain protein IPF-1/STF-1 is expressed in a subset of islet cells and promotes rat insulin 1 gene expression dependent on an intact E1 helix-loop-helix factor binding site.

Míreanna Comhchosúla

• Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes.
  le: Petersen, H V, et al.
  Foilsithe: (1994)
• IPF1, a homeodomain-containing transactivator of the insulin gene.
  le: Ohlsson, H, et al.
  Foilsithe: (1993)
• The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain.
  le: Peers, B, et al.
  Foilsithe: (1995)
• The LIM family transcription factor Isl-1 requires cAMP response element binding protein to promote somatostatin expression in pancreatic islet cells.
  le: Leonard, J, et al.
  Foilsithe: (1992)
• Suppression of transcription factor PDX-1/IPF1/STF-1/IDX-1 causes no decrease in insulin mRNA in MIN6 cells.
  le: Kajimoto, Y, et al.
  Foilsithe: (1997)