Probing a putative dantrolene-binding site on the cardiac ryanodine receptor

Dantrolene is an inhibitor of intracellular Ca(2+) release from skeletal muscle SR (sarcoplasmic reticulum). Direct photoaffinity labelling experiments using [(3)H]azidodantrolene and synthetic domain peptides have demonstrated that this drug targets amino acids 590–609 [termed DP1 (domain peptide 1...

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Main Authors: Paul-Pletzer, Kalanethee, Yamamoto, Takeshi, Ikemoto, Noriaki, Jimenez, Leslie S., Morimoto, Hiromi, Williams, Philip G., Ma, Jianjie, Parness, Jerome
Formato: Artigo
Idioma:Inglês
Publicado: Portland Press Ltd. 2005
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1135024/
https://ncbi.nlm.nih.gov/pubmed/15656791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041336
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