Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain.

The actions of recombinant human fibroblast collagenase (MMP1), purified polymorphonuclear leucocyte collagenase (MMP8) and their N-terminal catalytic domain fragments against cartilage aggrecan and an aggrecan G1-G2 fragment have been investigated in vitro. After activation with recombinant human s...

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Main Authors: Fosang, A J, Last, K, Knäuper, V, Neame, P J, Murphy, G, Hardingham, T E, Tschesche, H, Hamilton, J A
Format: Artigo
Jezik:Inglês
Izdano: 1993
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134849/
https://ncbi.nlm.nih.gov/pubmed/8216228
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