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Central core disease mutations R4892W, I4897T and G4898E in the ryanodine receptor isoform 1 reduce the Ca(2+) sensitivity and amplitude of Ca(2+)-dependent Ca(2+) release
Three CCD (central core disease) mutants, R4892W (Arg(4892)→Trp), I4897T and G4898E, in the pore region of the skeletal-muscle Ca(2+)-release channel RyR1 (ryanodine receptor 1) were characterized using a newly developed assay that monitored Ca(2+) release in the presence of Ca(2+) uptake in microso...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1133812/ https://ncbi.nlm.nih.gov/pubmed/15175001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040580 |
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