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Ryanodine sensitizes the cardiac Ca(2+) release channel (ryanodine receptor isoform 2) to Ca(2+) activation and dissociates as the channel is closed by Ca(2+) depletion

In single-channel recordings, the rabbit cardiac Ca(2+) release channel (RyR2) is converted to a fully open subconductance state with about 50% of full conductance by micromolar concentrations of ryanodine. At +30 mV, corresponding to a luminal to cytoplasmic cation current, the probability of openi...

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Detalhes bibliográficos
Main Authors: Du, Guo Guang, Guo, Xinghua, Khanna, Vijay K., MacLennan, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC61091/
https://ncbi.nlm.nih.gov/pubmed/11698671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.241516898
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