Effects of DNA-binding drugs on T4 DNA ligase.

A number of DNA intercalating and externally binding drugs have been found to inhibit nick sealing, cohesive and blunt end ligation, AMP-dependent DNA topoisomerization and EDTA-induced DNA nicking mediated by bacteriophage T4 DNA ligase. The inhibition seems to arise from drug-substrate interaction...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Montecucco, A, Pedrali-Noy, G, Spadari, S, Lestingi, M, Ciarrocchi, G
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1990
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1131142/
https://ncbi.nlm.nih.gov/pubmed/2156493
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