Effects of DNA-binding drugs on T4 DNA ligase.

A number of DNA intercalating and externally binding drugs have been found to inhibit nick sealing, cohesive and blunt end ligation, AMP-dependent DNA topoisomerization and EDTA-induced DNA nicking mediated by bacteriophage T4 DNA ligase. The inhibition seems to arise from drug-substrate interaction...

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Bibliografske podrobnosti
Main Authors: Montecucco, A, Pedrali-Noy, G, Spadari, S, Lestingi, M, Ciarrocchi, G
Format: Artigo
Jezik:Inglês
Izdano: 1990
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1131142/
https://ncbi.nlm.nih.gov/pubmed/2156493
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