Mutations Abrogating the RNase Activity in Glycoprotein E(rns) of the Pestivirus Classical Swine Fever Virus Lead to Virus Attenuation

Classical swine fever (CSF) is a severe hemorrhagic disease of swine caused by the pestivirus CSF virus (CSFV). Amino acid exchanges or deletions introduced by site-directed mutagenesis into the putative active site of the RNase residing in the glycoprotein E(rns) of CSFV abolished the enzymatic act...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Meyers, Gregor, Saalmüller, Armin, Büttner, Mathias
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Pathogenesis and Immunity
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC113076/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10559339/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.12.10224-10235.1999
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