Mutations Abrogating the RNase Activity in Glycoprotein E(rns) of the Pestivirus Classical Swine Fever Virus Lead to Virus Attenuation

Classical swine fever (CSF) is a severe hemorrhagic disease of swine caused by the pestivirus CSF virus (CSFV). Amino acid exchanges or deletions introduced by site-directed mutagenesis into the putative active site of the RNase residing in the glycoprotein E(rns) of CSFV abolished the enzymatic act...

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Bibliographic Details
Main Authors: Meyers, Gregor, Saalmüller, Armin, Büttner, Mathias
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC113076/
https://ncbi.nlm.nih.gov/pubmed/10559339
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