Mutations Abrogating the RNase Activity in Glycoprotein E(rns) of the Pestivirus Classical Swine Fever Virus Lead to Virus Attenuation

Classical swine fever (CSF) is a severe hemorrhagic disease of swine caused by the pestivirus CSF virus (CSFV). Amino acid exchanges or deletions introduced by site-directed mutagenesis into the putative active site of the RNase residing in the glycoprotein E(rns) of CSFV abolished the enzymatic act...

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Bibliografske podrobnosti

izdano v:	J Virol
Principais autores:	Meyers, Gregor, Saalmüller, Armin, Büttner, Mathias
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 1999
Teme:	Pathogenesis and Immunity
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC113076/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10559339/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.12.10224-10235.1999
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