Mutations Abrogating the RNase Activity in Glycoprotein E(rns) of the Pestivirus Classical Swine Fever Virus Lead to Virus Attenuation
Classical swine fever (CSF) is a severe hemorrhagic disease of swine caused by the pestivirus CSF virus (CSFV). Amino acid exchanges or deletions introduced by site-directed mutagenesis into the putative active site of the RNase residing in the glycoprotein E(rns) of CSFV abolished the enzymatic act...
Guardat en:
| Publicat a: | J Virol |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
1999
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC113076/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10559339/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.12.10224-10235.1999 |
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