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Mutations Abrogating the RNase Activity in Glycoprotein E(rns) of the Pestivirus Classical Swine Fever Virus Lead to Virus Attenuation
Classical swine fever (CSF) is a severe hemorrhagic disease of swine caused by the pestivirus CSF virus (CSFV). Amino acid exchanges or deletions introduced by site-directed mutagenesis into the putative active site of the RNase residing in the glycoprotein E(rns) of CSFV abolished the enzymatic act...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
1999
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC113076/ https://ncbi.nlm.nih.gov/pubmed/10559339 |
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